Genetic deficiency of flavin containing monooxygenase 3 (Fmo3) protects against thrombosis but has only a minor effect on plasma lipid levels

OBJECTIVE. FMO3 converts bacterial-derived trimethylamine to trimethylamine N-oxide (TMAO), an independent risk factor for cardiovascular disease. We generated FMO3 knockout (KO) mouse to study its effects on plasma TMAO, lipids, glucose/insulin metabolism, thrombosis, and atherosclerosis. APPROACH...

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Detalhes bibliográficos
Publicado no:Arterioscler Thromb Vasc Biol
Main Authors: Shih, Diana M., Zhu, Weifei, Schugar, Rebecca C., Meng, Yonghong, Jia, Xun, Miikeda, Aika, Wang, Zeneng, Zieger, Marina, Lee, Richard, Graham, Mark, Allayee, Hooman, Cantor, Rita M., Mueller, Christian, Brown, J. Mark, Hazen, Stanley L., Lusis, Aldons J.
Formato: Artigo
Idioma:Inglês
Publicado em: 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6531332/
https://ncbi.nlm.nih.gov/pubmed/31070450
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/ATVBAHA.119.312592
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