The TMAO-Producing Enzyme Flavin-Containing Monooxygenase 3 (FMO3) Regulates Obesity and the Beiging of White Adipose Tissue

Emerging evidence suggests that microbes resident in the human intestine represent a key environmental factor contributing to obesity-associated disorders. Here we demonstrate that the gut microbiota-initiated trimethylamine-N-oxide (TMAO)-generating pathway is linked to obesity and energy metabolis...

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Published in:Cell Rep
Main Authors: Schugar, Rebecca C., Shih, Diana M., Warrier, Manya, Helsley, Robert N., Burrows, Amy, Ferguson, Daniel, Brown, Amanda L., Gromovsky, Anthony D., Heine, Markus, Chatterjee, Arunachal, Li, Lin, Li, Xinmin S., Wang, Zeneng, Willard, Belinda, Meng, YongHong, Kim, Hanjun, Che, Nam, Pan, Calvin, Lee, Richard G., Crooke, Rosanne M., Graham, Mark J., Morton, Richard E., Langefeld, Carl D., Das, Swapan K., Rudel, Lawrence L., Zein, Nizar, McCullough, Arthur J., Dasarathy, Srinivasan, Tang, W.H. Wilson, Erokwu, Bernadette O., Flask, Chris A., Laakso, Markku, Civelek, Mete, Naga Prasad, Sathyamangla V., Heeren, Joerg, Lusis, Aldons J., Hazen, Stanley L., Brown, J. Mark
Format: Artigo
Language:Inglês
Published: 2017
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5672822/
https://ncbi.nlm.nih.gov/pubmed/28636934
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2017.05.077
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