Genetic deficiency of flavin containing monooxygenase 3 (Fmo3) protects against thrombosis but has only a minor effect on plasma lipid levels

OBJECTIVE. FMO3 converts bacterial-derived trimethylamine to trimethylamine N-oxide (TMAO), an independent risk factor for cardiovascular disease. We generated FMO3 knockout (KO) mouse to study its effects on plasma TMAO, lipids, glucose/insulin metabolism, thrombosis, and atherosclerosis. APPROACH...

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書誌詳細
出版年:Arterioscler Thromb Vasc Biol
主要な著者: Shih, Diana M., Zhu, Weifei, Schugar, Rebecca C., Meng, Yonghong, Jia, Xun, Miikeda, Aika, Wang, Zeneng, Zieger, Marina, Lee, Richard, Graham, Mark, Allayee, Hooman, Cantor, Rita M., Mueller, Christian, Brown, J. Mark, Hazen, Stanley L., Lusis, Aldons J.
フォーマット: Artigo
言語:Inglês
出版事項: 2019
主題:
Article
オンライン･アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC6531332/
https://ncbi.nlm.nih.gov/pubmed/31070450
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/ATVBAHA.119.312592
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