Flavin-containing monooxygenase 3 (FMO3) role in busulphan metabolic pathway

Busulphan (Bu) is an alkylating agent used in the conditioning regimen prior to hematopoietic stem cell transplantation (HSCT). Bu is extensively metabolized in the liver via conjugations with glutathione to form the intermediate metabolite (sulfonium ion) which subsequently is degraded to tetrahydr...

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Bibliografske podrobnosti
izdano v:PLoS One
Main Authors: El-Serafi, Ibrahim, Terelius, Ylva, Abedi-Valugerdi, Manuchehr, Naughton, Seán, Saghafian, Maryam, Moshfegh, Ali, Mattsson, Jonas, Potácová, Zuzana, Hassan, Moustapha
Format: Artigo
Jezik:Inglês
Izdano: Public Library of Science 2017
Teme:
Research Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC5679629/
https://ncbi.nlm.nih.gov/pubmed/29121650
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0187294
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