Flavin-containing monooxygenase 3 (FMO3) role in busulphan metabolic pathway

Busulphan (Bu) is an alkylating agent used in the conditioning regimen prior to hematopoietic stem cell transplantation (HSCT). Bu is extensively metabolized in the liver via conjugations with glutathione to form the intermediate metabolite (sulfonium ion) which subsequently is degraded to tetrahydr...

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Detalles Bibliográficos
Publicado en:PLoS One
Autores principales: El-Serafi, Ibrahim, Terelius, Ylva, Abedi-Valugerdi, Manuchehr, Naughton, Seán, Saghafian, Maryam, Moshfegh, Ali, Mattsson, Jonas, Potácová, Zuzana, Hassan, Moustapha
Formato: Artigo
Lenguaje:Inglês
Publicado: Public Library of Science 2017
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Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5679629/
https://ncbi.nlm.nih.gov/pubmed/29121650
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0187294
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