Genetic deficiency of flavin containing monooxygenase 3 (Fmo3) protects against thrombosis but has only a minor effect on plasma lipid levels

OBJECTIVE. FMO3 converts bacterial-derived trimethylamine to trimethylamine N-oxide (TMAO), an independent risk factor for cardiovascular disease. We generated FMO3 knockout (KO) mouse to study its effects on plasma TMAO, lipids, glucose/insulin metabolism, thrombosis, and atherosclerosis. APPROACH...

Descripción completa

Guardado en:
Detalles Bibliográficos
Publicado en:Arterioscler Thromb Vasc Biol
Autores principales: Shih, Diana M., Zhu, Weifei, Schugar, Rebecca C., Meng, Yonghong, Jia, Xun, Miikeda, Aika, Wang, Zeneng, Zieger, Marina, Lee, Richard, Graham, Mark, Allayee, Hooman, Cantor, Rita M., Mueller, Christian, Brown, J. Mark, Hazen, Stanley L., Lusis, Aldons J.
Formato: Artigo
Lenguaje:Inglês
Publicado: 2019
Materias:
Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6531332/
https://ncbi.nlm.nih.gov/pubmed/31070450
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/ATVBAHA.119.312592
Etiquetas: Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!

Ejemplares similares