Apolipoprotein A-I anti-tumor activity targets cancer cell metabolism

著者: Zamanian-Daryoush, Maryam, Lindner, Daniel J., Buffa, Jennifer, Gopalan, Banu, Na, Jie, Hazen, Stanley L., DiDonato, Joseph A.
出版年 Oncotarget (2020)

Myeloperoxidase-mediated protein lysine oxidation generates 2-aminoadipic acid and lysine nitrile in vivo

著者: Lin, Hongqiao, Levison, Bruce S., Buffa, Jennifer A., Huang, Ying, Fu, Xiaoming, Wang, Zeneng, Gogonea, Valentin, DiDonato, Joseph A., Hazen, Stanley L.
出版年 Free Radic Biol Med (2017)

(2)H(2)O-Based HDL Turnover Method for the Assessment of Dynamic HDL Function in Mice

著者: Kasumov, Takhar, Willard, Belinda, Li, Ling, Li, Min, Conger, Heather, Buffa, Jennifer A., Previs, Stephen, McCullough, Arthur, Hazen, Stanley L., Smith, Jonathan D.
出版事項 2013

Gut Microbiota-Dependent Trimethylamine N-oxide (TMAO) Pathway Contributes to Both Development of Renal Insufficiency and Mortality Risk in Chronic Kidney Disease

著者: Wilson Tang, W. H., Wang, Zeneng, Kennedy, David J., Wu, Yuping, Buffa, Jennifer A., Agatisa-Boyle, Brendan, Li, Xinmin S., Levison, Bruce S., Hazen, Stanley L.
出版年 Circ Res (2014)

Prognostic value of choline and betaine depends on intestinal microbiota-generated metabolite trimethylamine-N-oxide

著者: Wang, Zeneng, Tang, W. H. Wilson, Buffa, Jennifer A., Fu, Xiaoming, Britt, Earl B., Koeth, Robert A., Levison, Bruce S., Fan, Yiying, Wu, Yuping, Hazen, Stanley L.
出版事項 2014

Myeloid-specific genetic ablation of ATP-binding cassette transporter ABCA1 is protective against cancer

著者: Zamanian-Daryoush, Maryam, Lindner, Daniel J., DiDonato, Joseph A., Wagner, Matthew, Buffa, Jennifer, Rayman, Patricia, Parks, John S., Westerterp, Marit, Tall, Alan R., Hazen, Stanley L.
出版年 Oncotarget (2017)

Targeted inhibition of gut microbial TMAO production reduces renal tubulointerstitial fibrosis and functional impairment in a murine model of chronic kidney disease

著者: Gupta, Nilaksh, Buffa, Jennifer A., Roberts, Adam B, Sangwan, Naseer, Skye, Sarah M., Li, Lin, Ho, Karen J., Varga, John, DiDonato, Joseph A., Tang, W.H. Wilson, Hazen, Stanley L.
出版年 Arterioscler Thromb Vasc Biol (2020)

Transmission of Atherosclerosis Susceptibility with Gut Microbial Transplantation

著者: Gregory, Jill C., Buffa, Jennifer A., Org, Elin, Wang, Zeneng, Levison, Bruce S., Zhu, Weifei, Wagner, Matthew A., Bennett, Brian J., Li, Lin, DiDonato, Joseph A., Lusis, Aldons J., Hazen, Stanley L.
出版年 J Biol Chem (2015)

Site-specific 5-hydroxytryptophan incorporation into apolipoprotein A-I impairs cholesterol efflux activity and high-density lipoprotein biogenesis

著者: Zamanian-Daryoush, Maryam, Gogonea, Valentin, DiDonato, Anthony J., Buffa, Jennifer A., Choucair, Ibrahim, Levison, Bruce S., Hughes, Randall A., Ellington, Andrew D., Huang, Ying, Li, Xinmin S., DiDonato, Joseph A., Hazen, Stanley L.
出版年 J Biol Chem (2020)

Eosinophil Peroxidase Catalyzed Protein Carbamylation Participates in Asthma

著者: Wang, Zeneng, DiDonato, Joseph A., Buffa, Jennifer, Comhair, Suzy A., Aronica, Mark A., Dweik, Raed A., Lee, Nancy A., Lee, James J., Thomassen, Mary Jane, Kavuru, Mani, Erzurum, Serpil C., Hazen, Stanley L.
出版年 J Biol Chem (2016)

Small molecule inhibition of gut microbial choline trimethylamine lyase activity alters host cholesterol and bile acid metabolism

著者: Pathak, Preeti, Helsley, Robert N., Brown, Amanda L., Buffa, Jennifer A., Choucair, Ibrahim, Nemet, Ina, Gogonea, Camelia Baleanu, Gogonea, Valentin, Wang, Zeneng, Garcia-Garcia, Jose Carlos, Cai, Lei, Temel, Ryan, Sangwan, Naseer, Hazen, Stanley L., Brown, J. Mark
出版年 Am J Physiol Heart Circ Physiol (2020)

γ–Butyrobetaine is a pro-atherogenic intermediate in gut microbial metabolism of L-carnitine to TMAO

著者: Koeth, Robert A., Levison, Bruce S., Culley, Miranda K., Buffa, Jennifer A., Wang, Zeneng, Gregory, Jill C., Org, Elin, Wu, Yuping, Li, Lin, Smith, Jonathan D., Wilson Tang, W. H., DiDonato, Joseph A., Lusis, Aldons J., Hazen, Stanley L.
出版年 Cell Metab (2014)

A Systematic Investigation of Structure/Function Requirements for the Apolipoprotein A-I/Lecithin Cholesterol Acyltransferase Interaction Loop of High-density Lipoprotein

著者: Gu, Xiaodong, Wu, Zhiping, Huang, Ying, Wagner, Matthew A., Baleanu-Gogonea, Camelia, Mehl, Ryan A., Buffa, Jennifer A., DiDonato, Anthony J., Hazen, Leah B., Fox, Paul L., Gogonea, Valentin, Parks, John S., DiDonato, Joseph A., Hazen, Stanley L.
出版年 J Biol Chem (2016)

The Cardioprotective Protein Apolipoprotein A1 Promotes Potent Anti-tumorigenic Effects

著者: Zamanian-Daryoush, Maryam, Lindner, Daniel, Tallant, Thomas C., Wang, Zeneng, Buffa, Jennifer, Klipfell, Elizabeth, Parker, Yvonne, Hatala, Denise, Parsons-Wingerter, Patricia, Rayman, Pat, Yusufishaq, Mohamed Sharif S., Fisher, Edward A., Smith, Jonathan D., Finke, Jim, DiDonato, Joseph A., Hazen, Stanley L.
出版事項 2013

Effects of native and myeloperoxidase-modified apolipoprotein A-I on reverse cholesterol transport and atherosclerosis in mice

著者: Hewing, Bernd, Parathath, Saj, Barrett, Tessa, Chung, Wing Ki Kellie, Astudillo, Yaritzy M., Hamada, Tadateru, Ramkhelawon, Bhama, Tallant, Thomas C., Yusufishaq, Mohamed Shaif S., DiDonato, Joseph A., Huang, Ying, Buffa, Jennifer, Berisha, Stela Z., Smith, Jonathan D., Hazen, Stanley L., Fisher, Edward A.
出版事項 2014

Non-lethal inhibition of gut microbial trimethylamine production for the treatment of atherosclerosis

著者: Wang, Zeneng, Roberts, Adam B., Buffa, Jennifer A., Levison, Bruce S., Zhu, Weifei, Org, Elin, Gu, Xiaodong, Huang, Ying, Zamanian-Daryoush, Maryam, Culley, Miranda K., DiDonato, Anthony J., Fu, Xiaoming, Hazen, Jennie E., Krajcik, Daniel, DiDonato, Joseph A., Lusis, Aldons J., Hazen, Stanley L.
出版年 Cell (2015)

Gut microbial metabolite TMAO enhances platelet hyperreactivity and thrombosis risk

著者: Zhu, Weifei, Gregory, Jill C., Org, Elin, Buffa, Jennifer A., Gupta, Nilaksh, Wang, Zeneng, Li, Lin, Fu, Xiaoming, Wu, Yuping, Mehrabian, Margarete, Sartor, R. Balfour, McIntyre, Thomas M., Silverstein, Roy L., Tang, W.H. Wilson, DiDonato, Joseph A., Brown, J. Mark, Lusis, Aldons J., Hazen, Stanley L.
出版年 Cell (2016)

Gut microbes impact stroke severity via the trimethylamine-N-oxide pathway

著者: Zhu, Weifei, Romano, Kymberleigh A., Li, Lin, Buffa, Jennifer A., Sangwan, Naseer, Prakash, Prem, Tittle, Aaron N., Li, Xinmin S., Fu, Xiaoming, Androjna, Charlie, DiDonato, Anthony J., Brinson, Kimberly, Trapp, Bruce D., Fischbach, Michael A., Rey, Federico E., Hajjar, Adeline M., DiDonato, Joseph A., Hazen, Stanley L.
出版年 Cell Host Microbe (2021)

Intestinal microbiota metabolism of L-carnitine, a nutrient in red meat, promotes atherosclerosis

著者: Koeth, Robert A., Wang, Zeneng, Levison, Bruce S., Buffa, Jennifer A., Org, Elin, Sheehy, Brendan T., Britt, Earl B., Fu, Xiaoming, Wu, Yuping, Li, Lin, Smith, Jonathan D., DiDonato, Joseph A., Chen, Jun, Li, Hongzhe, Wu, Gary D., Lewis, James D., Warrier, Manya, Brown, J. Mark, Krauss, Ronald M., Tang, W. H. Wilson, Bushman, Frederic D., Lusis, Aldons J., Hazen, Stanley L.
出版事項 2013

Untargeted metabolomics identifies trimethyllysine, a TMAO-producing nutrient precursor, as a predictor of incident cardiovascular disease risk

著者: Li, Xinmin S., Wang, Zeneng, Cajka, Tomas, Buffa, Jennifer A., Nemet, Ina, Hurd, Alex G., Gu, Xiaodong, Skye, Sarah M., Roberts, Adam B., Wu, Yuping, Li, Lin, Shahen, Christopher J., Wagner, Matthew A., Hartiala, Jaana A., Kerby, Robert L., Romano, Kymberleigh A., Han, Yi, Obeid, Slayman, Lüscher, Thomas F., Allayee, Hooman, Rey, Federico E., DiDonato, Joseph A., Fiehn, Oliver, Tang, W.H. Wilson, Hazen, Stanley L.
出版年 JCI Insight (2018)