Apolipoprotein A-I anti-tumor activity targets cancer cell metabolism

מאת Zamanian-Daryoush, Maryam, Lindner, Daniel J., Buffa, Jennifer, Gopalan, Banu, Na, Jie, Hazen, Stanley L., DiDonato, Joseph A.
הוצא לאור ב Oncotarget (2020)

Myeloperoxidase-mediated protein lysine oxidation generates 2-aminoadipic acid and lysine nitrile in vivo

מאת Lin, Hongqiao, Levison, Bruce S., Buffa, Jennifer A., Huang, Ying, Fu, Xiaoming, Wang, Zeneng, Gogonea, Valentin, DiDonato, Joseph A., Hazen, Stanley L.
הוצא לאור ב Free Radic Biol Med (2017)

(2)H(2)O-Based HDL Turnover Method for the Assessment of Dynamic HDL Function in Mice

מאת Kasumov, Takhar, Willard, Belinda, Li, Ling, Li, Min, Conger, Heather, Buffa, Jennifer A., Previs, Stephen, McCullough, Arthur, Hazen, Stanley L., Smith, Jonathan D.
יצא לאור 2013

Gut Microbiota-Dependent Trimethylamine N-oxide (TMAO) Pathway Contributes to Both Development of Renal Insufficiency and Mortality Risk in Chronic Kidney Disease

מאת Wilson Tang, W. H., Wang, Zeneng, Kennedy, David J., Wu, Yuping, Buffa, Jennifer A., Agatisa-Boyle, Brendan, Li, Xinmin S., Levison, Bruce S., Hazen, Stanley L.
הוצא לאור ב Circ Res (2014)

Prognostic value of choline and betaine depends on intestinal microbiota-generated metabolite trimethylamine-N-oxide

מאת Wang, Zeneng, Tang, W. H. Wilson, Buffa, Jennifer A., Fu, Xiaoming, Britt, Earl B., Koeth, Robert A., Levison, Bruce S., Fan, Yiying, Wu, Yuping, Hazen, Stanley L.
יצא לאור 2014

Myeloid-specific genetic ablation of ATP-binding cassette transporter ABCA1 is protective against cancer

מאת Zamanian-Daryoush, Maryam, Lindner, Daniel J., DiDonato, Joseph A., Wagner, Matthew, Buffa, Jennifer, Rayman, Patricia, Parks, John S., Westerterp, Marit, Tall, Alan R., Hazen, Stanley L.
הוצא לאור ב Oncotarget (2017)

Targeted inhibition of gut microbial TMAO production reduces renal tubulointerstitial fibrosis and functional impairment in a murine model of chronic kidney disease

מאת Gupta, Nilaksh, Buffa, Jennifer A., Roberts, Adam B, Sangwan, Naseer, Skye, Sarah M., Li, Lin, Ho, Karen J., Varga, John, DiDonato, Joseph A., Tang, W.H. Wilson, Hazen, Stanley L.
הוצא לאור ב Arterioscler Thromb Vasc Biol (2020)

Transmission of Atherosclerosis Susceptibility with Gut Microbial Transplantation

מאת Gregory, Jill C., Buffa, Jennifer A., Org, Elin, Wang, Zeneng, Levison, Bruce S., Zhu, Weifei, Wagner, Matthew A., Bennett, Brian J., Li, Lin, DiDonato, Joseph A., Lusis, Aldons J., Hazen, Stanley L.
הוצא לאור ב J Biol Chem (2015)

Site-specific 5-hydroxytryptophan incorporation into apolipoprotein A-I impairs cholesterol efflux activity and high-density lipoprotein biogenesis

מאת Zamanian-Daryoush, Maryam, Gogonea, Valentin, DiDonato, Anthony J., Buffa, Jennifer A., Choucair, Ibrahim, Levison, Bruce S., Hughes, Randall A., Ellington, Andrew D., Huang, Ying, Li, Xinmin S., DiDonato, Joseph A., Hazen, Stanley L.
הוצא לאור ב J Biol Chem (2020)

Eosinophil Peroxidase Catalyzed Protein Carbamylation Participates in Asthma

מאת Wang, Zeneng, DiDonato, Joseph A., Buffa, Jennifer, Comhair, Suzy A., Aronica, Mark A., Dweik, Raed A., Lee, Nancy A., Lee, James J., Thomassen, Mary Jane, Kavuru, Mani, Erzurum, Serpil C., Hazen, Stanley L.
הוצא לאור ב J Biol Chem (2016)

Small molecule inhibition of gut microbial choline trimethylamine lyase activity alters host cholesterol and bile acid metabolism

מאת Pathak, Preeti, Helsley, Robert N., Brown, Amanda L., Buffa, Jennifer A., Choucair, Ibrahim, Nemet, Ina, Gogonea, Camelia Baleanu, Gogonea, Valentin, Wang, Zeneng, Garcia-Garcia, Jose Carlos, Cai, Lei, Temel, Ryan, Sangwan, Naseer, Hazen, Stanley L., Brown, J. Mark
הוצא לאור ב Am J Physiol Heart Circ Physiol (2020)

γ–Butyrobetaine is a pro-atherogenic intermediate in gut microbial metabolism of L-carnitine to TMAO

מאת Koeth, Robert A., Levison, Bruce S., Culley, Miranda K., Buffa, Jennifer A., Wang, Zeneng, Gregory, Jill C., Org, Elin, Wu, Yuping, Li, Lin, Smith, Jonathan D., Wilson Tang, W. H., DiDonato, Joseph A., Lusis, Aldons J., Hazen, Stanley L.
הוצא לאור ב Cell Metab (2014)

A Systematic Investigation of Structure/Function Requirements for the Apolipoprotein A-I/Lecithin Cholesterol Acyltransferase Interaction Loop of High-density Lipoprotein

מאת Gu, Xiaodong, Wu, Zhiping, Huang, Ying, Wagner, Matthew A., Baleanu-Gogonea, Camelia, Mehl, Ryan A., Buffa, Jennifer A., DiDonato, Anthony J., Hazen, Leah B., Fox, Paul L., Gogonea, Valentin, Parks, John S., DiDonato, Joseph A., Hazen, Stanley L.
הוצא לאור ב J Biol Chem (2016)

The Cardioprotective Protein Apolipoprotein A1 Promotes Potent Anti-tumorigenic Effects

מאת Zamanian-Daryoush, Maryam, Lindner, Daniel, Tallant, Thomas C., Wang, Zeneng, Buffa, Jennifer, Klipfell, Elizabeth, Parker, Yvonne, Hatala, Denise, Parsons-Wingerter, Patricia, Rayman, Pat, Yusufishaq, Mohamed Sharif S., Fisher, Edward A., Smith, Jonathan D., Finke, Jim, DiDonato, Joseph A., Hazen, Stanley L.
יצא לאור 2013

Effects of native and myeloperoxidase-modified apolipoprotein A-I on reverse cholesterol transport and atherosclerosis in mice

מאת Hewing, Bernd, Parathath, Saj, Barrett, Tessa, Chung, Wing Ki Kellie, Astudillo, Yaritzy M., Hamada, Tadateru, Ramkhelawon, Bhama, Tallant, Thomas C., Yusufishaq, Mohamed Shaif S., DiDonato, Joseph A., Huang, Ying, Buffa, Jennifer, Berisha, Stela Z., Smith, Jonathan D., Hazen, Stanley L., Fisher, Edward A.
יצא לאור 2014

Non-lethal inhibition of gut microbial trimethylamine production for the treatment of atherosclerosis

מאת Wang, Zeneng, Roberts, Adam B., Buffa, Jennifer A., Levison, Bruce S., Zhu, Weifei, Org, Elin, Gu, Xiaodong, Huang, Ying, Zamanian-Daryoush, Maryam, Culley, Miranda K., DiDonato, Anthony J., Fu, Xiaoming, Hazen, Jennie E., Krajcik, Daniel, DiDonato, Joseph A., Lusis, Aldons J., Hazen, Stanley L.
הוצא לאור ב Cell (2015)

Gut microbial metabolite TMAO enhances platelet hyperreactivity and thrombosis risk

מאת Zhu, Weifei, Gregory, Jill C., Org, Elin, Buffa, Jennifer A., Gupta, Nilaksh, Wang, Zeneng, Li, Lin, Fu, Xiaoming, Wu, Yuping, Mehrabian, Margarete, Sartor, R. Balfour, McIntyre, Thomas M., Silverstein, Roy L., Tang, W.H. Wilson, DiDonato, Joseph A., Brown, J. Mark, Lusis, Aldons J., Hazen, Stanley L.
הוצא לאור ב Cell (2016)

Gut microbes impact stroke severity via the trimethylamine-N-oxide pathway

מאת Zhu, Weifei, Romano, Kymberleigh A., Li, Lin, Buffa, Jennifer A., Sangwan, Naseer, Prakash, Prem, Tittle, Aaron N., Li, Xinmin S., Fu, Xiaoming, Androjna, Charlie, DiDonato, Anthony J., Brinson, Kimberly, Trapp, Bruce D., Fischbach, Michael A., Rey, Federico E., Hajjar, Adeline M., DiDonato, Joseph A., Hazen, Stanley L.
הוצא לאור ב Cell Host Microbe (2021)

Intestinal microbiota metabolism of L-carnitine, a nutrient in red meat, promotes atherosclerosis

מאת Koeth, Robert A., Wang, Zeneng, Levison, Bruce S., Buffa, Jennifer A., Org, Elin, Sheehy, Brendan T., Britt, Earl B., Fu, Xiaoming, Wu, Yuping, Li, Lin, Smith, Jonathan D., DiDonato, Joseph A., Chen, Jun, Li, Hongzhe, Wu, Gary D., Lewis, James D., Warrier, Manya, Brown, J. Mark, Krauss, Ronald M., Tang, W. H. Wilson, Bushman, Frederic D., Lusis, Aldons J., Hazen, Stanley L.
יצא לאור 2013

Untargeted metabolomics identifies trimethyllysine, a TMAO-producing nutrient precursor, as a predictor of incident cardiovascular disease risk

מאת Li, Xinmin S., Wang, Zeneng, Cajka, Tomas, Buffa, Jennifer A., Nemet, Ina, Hurd, Alex G., Gu, Xiaodong, Skye, Sarah M., Roberts, Adam B., Wu, Yuping, Li, Lin, Shahen, Christopher J., Wagner, Matthew A., Hartiala, Jaana A., Kerby, Robert L., Romano, Kymberleigh A., Han, Yi, Obeid, Slayman, Lüscher, Thomas F., Allayee, Hooman, Rey, Federico E., DiDonato, Joseph A., Fiehn, Oliver, Tang, W.H. Wilson, Hazen, Stanley L.
הוצא לאור ב JCI Insight (2018)