Influence of Seeding Density and Extracellular Matrix on Bile Acid Transport and Mrp4 Expression in Sandwich-Cultured Mouse Hepatocytes

od Swift, Brandon, Brouwer, Kim L.R.
Izdano 2010

Hepatocellular Exposure of Troglitazone Metabolites in Rat Sandwich-Cultured Hepatocytes Lacking Bcrp and Mrp2: Interplay between Formation and Excretion

od Yang, Kyunghee, Brouwer, Kim L. R.
Izdano 2014

Identification of Hepatic Phospholipidosis Inducers in Sandwich-Cultured Rat Hepatocytes, a Physiologically Relevant Model, Reveals Altered Basolateral Uptake and Biliary Excretion...

od Ferslew, Brian C., Brouwer, Kim L. R.
Izdano 2014

Use of Sandwich-Cultured Human Hepatocytes to Predict Biliary Clearance of Angiotensin II Receptor Blockers and HMG-CoA Reductase Inhibitors

od Abe, Koji, Bridges, Arlene S., Brouwer, Kim L. R.
Izdano 2009

Integration of Preclinical and Clinical Data with Pharmacokinetic Modeling and Simulation to Evaluate Fexofenadine as a Probe for Hepatobiliary Transport Function

od Swift, Brandon, Tian, Xianbin, Brouwer, Kim L. R.
Izdano 2009

Evaluation of (99m)Technetium-Mebrofenin and (99m)Technetium-Sestamibi as Specific Probes for Hepatic Transport Protein Function in Rat and Human Hepatocytes

od Swift, Brandon, Yue, Wei, Brouwer, Kim L. R.
Izdano 2010

Knocking Down Breast Cancer Resistance Protein (Bcrp) by Adenoviral Vector-Mediated RNA Interference (RNAi) in Sandwich-Cultured Rat Hepatocytes: A Novel Tool to Assess the Contrib...

od Yue, Wei, Abe, Koji, Brouwer, Kim L. R.
Izdano 2009

Mechanistic Modeling of the Hepatic Disposition of Estradiol-17β-Glucuronide in Sandwich-Cultured Human Hepatocytes

od Ito, Katsuaki, Sjöstedt, Noora, Brouwer, Kim L.R.
Izdano u Drug Metab Dispos (2020)

Physiologically-Based Pharmacokinetic (PBPK) Model of Morphine and Morphine-3-Glucuronide in Nonalcoholic Steatohepatitis (NASH)

od Sjöstedt, Noora, Neuhoff, Sibylle, Brouwer, Kim L.R.
Izdano u Clin Pharmacol Ther (2020)

Methods to Evaluate Biliary Excretion of Drugs in Humans: an Updated Review

od Ghibellini, Giulia, Leslie, Elaine M., Brouwer, Kim L.R.
Izdano 2006

Sandwich-Cultured Hepatocytes: An In Vitro Model to Evaluate Hepatobiliary Transporter-Based Drug Interactions and Hepatotoxicity

od Swift, Brandon, Pfeifer, Nathan D., Brouwer, Kim L.R.
Izdano 2010

Hepatic Basolateral Efflux Contributes Significantly to Rosuvastatin Disposition I: Characterization of Basolateral Versus Biliary Clearance Using a Novel Protocol in Sandwich-Cult...

od Pfeifer, Nathan D., Yang, Kyunghee, Brouwer, Kim L. R.
Izdano 2013

Effect of Liver Disease on Hepatic Transporter Expression and Function

od Thakkar, Nilay, Slizgi, Jason R., Brouwer, Kim L. R.
Izdano u J Pharm Sci (2017)

In Vitro Biliary Clearance of Angiotensin II Receptor Blockers and HMG-CoA Reductase Inhibitors in Sandwich-Cultured Rat Hepatocytes: Comparison to In Vivo Biliary Clearance

od Abe, Koji, Bridges, Arlene S., Yue, Wei, Brouwer, Kim L. R.
Izdano 2008

Sulindac and Its Metabolites Inhibit Multiple Transport Proteins in Rat and Human Hepatocytes

od Lee, Jin Kyung, Paine, Mary F., Brouwer, Kim L. R.
Izdano 2010

Effect of a Common Genetic Variant (p.V444A) in the Bile Salt Export Pump on the Inhibition of Bile Acid Transport by Cholestatic Medications

od Ali, Izna, Khalid, Seher, Stieger, Bruno, Brouwer, Kim L.R.
Izdano u Mol Pharm (2019)

Novel Insights into the Organic Solute Transporter Alpha/Beta, OSTα/β: From the Bench to the Bedside

od Beaudoin, James J., Brouwer, Kim L. R., Malinen, Melina M.
Izdano u Pharmacol Ther (2020)

Role of Multidrug Resistance–Associated Protein 4 in the Basolateral Efflux of Hepatically Derived Enalaprilat

od Ferslew, Brian C., Köck, Kathleen, Bridges, Arlene S., Brouwer, Kim L. R.
Izdano 2014

Species Differences in Hepatobiliary Disposition of Taurocholic Acid in Human and Rat Sandwich-Cultured Hepatocytes: Implications for Drug-Induced Liver Injury

od Yang, Kyunghee, Pfeifer, Nathan D., Köck, Kathleen, Brouwer, Kim L. R.
Izdano u J Pharmacol Exp Ther (2015)

Impact of reduced P‐glycoprotein function on digoxin concentrations in patients with dementia

od Ali, Izna, Guidone, Daniel, Nicolazzo, Joseph A., Brouwer, Kim L.R.
Izdano u Br J Clin Pharmacol (2019)