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Knocking Down Breast Cancer Resistance Protein (Bcrp) by Adenoviral Vector-Mediated RNA Interference (RNAi) in Sandwich-Cultured Rat Hepatocytes: A Novel Tool to Assess the Contribution of Bcrp to Drug Biliary Excretion

BCRP transports numerous drugs/derived metabolites and toxins, and exhibits overlapping substrate specificity with P-glycoprotein (P-gp) and multidrug resistance-associated protein 2 (MRP2). Assessing the contribution of BCRP to drug/metabolite biliary excretion in the intact hepatocytes remains a c...

תיאור מלא

שמור ב:
מידע ביבליוגרפי
Main Authors: Yue, Wei, Abe, Koji, Brouwer, Kim L. R.
פורמט: Artigo
שפה:Inglês
יצא לאור: 2009
נושאים:
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC3135650/
https://ncbi.nlm.nih.gov/pubmed/19105722
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/mp800100e
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