Hepatobiliary Disposition of Troglitazone and Metabolites in Rat and Human Sandwich-Cultured Hepatocytes: Use of Monte Carlo Simulations to Assess the Impact of Changes in Biliary Excretion on Troglitazone Sulfate Accumulation

This study examined the hepatobiliary disposition of troglitazone (TGZ) and metabolites [TGZ sulfate (TS), TGZ glucuronide (TG), and TGZ quinone (TQ)] over time in rat and human sandwich-cultured hepatocytes (SCH). Cells were incubated with TGZ; samples were analyzed for TGZ and metabolites by liqui...

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Detalhes bibliográficos
Main Authors: Lee, Jin Kyung, Marion, Tracy L., Abe, Koji, Lim, Changwon, Pollock, Gary M., Brouwer, Kim L. R.
Formato: Artigo
Idioma:Inglês
Publicado em: The American Society for Pharmacology and Experimental Therapeutics 2010
Assuntos:
Metabolism, Transport, and Pharmacogenomics
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2802476/
https://ncbi.nlm.nih.gov/pubmed/19801447
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/jpet.109.156653
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