Identification of Hepatic Phospholipidosis Inducers in Sandwich-Cultured Rat Hepatocytes, a Physiologically Relevant Model, Reveals Altered Basolateral Uptake and Biliary Excretion of Anionic Probe Substrates

Drug-induced phospholipidosis (PLD) is characterized by phospholipid accumulation within the lysosomes of affected tissues, resulting in lysosomal enlargement and laminar body inclusions. Numerous adverse effects and toxicities have been linked to PLD-inducing drugs, but it remains unknown whether d...

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Main Authors: Ferslew, Brian C., Brouwer, Kim L. R.
Formato: Artigo
Idioma:Inglês
Publicado: Oxford University Press 2014
Assuntos:
In Vitro Methods and Alternatives to Animals
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4038789/
https://ncbi.nlm.nih.gov/pubmed/24563379
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/toxsci/kfu033
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