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Physiologically-Based Pharmacokinetic (PBPK) Model of Morphine and Morphine-3-Glucuronide in Nonalcoholic Steatohepatitis (NASH)
Nonalcoholic steatohepatitis (NASH), the progressive form of nonalcoholic fatty liver disease, is increasing in prevalence. NASH-related alterations in hepatic protein expression (e.g., transporters) and in overall physiology may affect drug exposure by altering drug disposition and elimination. The...
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| Publicado no: | Clin Pharmacol Ther |
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| Main Authors: | , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2020
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7902445/ https://ncbi.nlm.nih.gov/pubmed/32897538 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cpt.2037 |
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