Influence of Morbid Obesity on the Pharmacokinetics of Morphine, Morphine-3-Glucuronide, and Morphine-6-Glucuronide

INTRODUCTION: Obesity is associated with many pathophysiological changes that may result in altered drug metabolism. The aim of this study is to investigate the influence of obesity on the pharmacokinetics of morphine, morphine-3-glucuronide (M3G), and morphine-6-glucuronide (M6G) through a combined...

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Detalhes bibliográficos
Publicado no:Clin Pharmacokinet
Main Authors: de Hoogd, Sjoerd, Välitalo, Pyry A. J., Dahan, Albert, van Kralingen, Simone, Coughtrie, Michael M. W., van Dongen, Eric P. A., van Ramshorst, Bert, Knibbe, Catherijne A. J.
Formato: Artigo
Idioma:Inglês
Publicado em: Springer International Publishing 2017
Assuntos:
Original Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5694499/
https://ncbi.nlm.nih.gov/pubmed/28510797
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s40262-017-0544-2
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