Influence of Morbid Obesity on the Pharmacokinetics of Morphine, Morphine-3-Glucuronide, and Morphine-6-Glucuronide

INTRODUCTION: Obesity is associated with many pathophysiological changes that may result in altered drug metabolism. The aim of this study is to investigate the influence of obesity on the pharmacokinetics of morphine, morphine-3-glucuronide (M3G), and morphine-6-glucuronide (M6G) through a combined...

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Vydáno v:Clin Pharmacokinet
Hlavní autoři: de Hoogd, Sjoerd, Välitalo, Pyry A. J., Dahan, Albert, van Kralingen, Simone, Coughtrie, Michael M. W., van Dongen, Eric P. A., van Ramshorst, Bert, Knibbe, Catherijne A. J.
Médium: Artigo
Jazyk:Inglês
Vydáno: Springer International Publishing 2017
Témata:
Original Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5694499/
https://ncbi.nlm.nih.gov/pubmed/28510797
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s40262-017-0544-2
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