Morbidly Obese Patients Exhibit Increased CYP2E1-Mediated Oxidation of Acetaminophen

INTRODUCTION: Acetaminophen (paracetamol) is mainly metabolized via glucuronidation and sulphation, while the minor pathway through cytochrome P450 (CYP) 2E1 is held responsible for hepatotoxicity. In obese patients, CYP2E1 activity is reported to be induced, thereby potentially worsening the safety...

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Vydáno v:Clin Pharmacokinet
Hlavní autoři: van Rongen, Anne, Välitalo, Pyry A. J., Peeters, Mariska Y. M., Boerma, Djamila, Huisman, Fokko W., van Ramshorst, Bert, van Dongen, Eric P. A., van den Anker, Johannes N., Knibbe, Catherijne A. J.
Médium: Artigo
Jazyk:Inglês
Vydáno: Springer International Publishing 2016
Témata:
Original Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4916199/
https://ncbi.nlm.nih.gov/pubmed/26818482
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s40262-015-0357-0
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