Morbidly Obese Patients Exhibit Increased CYP2E1-Mediated Oxidation of Acetaminophen

INTRODUCTION: Acetaminophen (paracetamol) is mainly metabolized via glucuronidation and sulphation, while the minor pathway through cytochrome P450 (CYP) 2E1 is held responsible for hepatotoxicity. In obese patients, CYP2E1 activity is reported to be induced, thereby potentially worsening the safety...

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Publicado en:Clin Pharmacokinet
Main Authors: van Rongen, Anne, Välitalo, Pyry A. J., Peeters, Mariska Y. M., Boerma, Djamila, Huisman, Fokko W., van Ramshorst, Bert, van Dongen, Eric P. A., van den Anker, Johannes N., Knibbe, Catherijne A. J.
Formato: Artigo
Idioma:Inglês
Publicado: Springer International Publishing 2016
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Original Research Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4916199/
https://ncbi.nlm.nih.gov/pubmed/26818482
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s40262-015-0357-0
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