Morbidly Obese Patients Exhibit Increased CYP2E1-Mediated Oxidation of Acetaminophen

INTRODUCTION: Acetaminophen (paracetamol) is mainly metabolized via glucuronidation and sulphation, while the minor pathway through cytochrome P450 (CYP) 2E1 is held responsible for hepatotoxicity. In obese patients, CYP2E1 activity is reported to be induced, thereby potentially worsening the safety...

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Bibliografiska uppgifter
I publikationen:Clin Pharmacokinet
Huvudupphovsmän: van Rongen, Anne, Välitalo, Pyry A. J., Peeters, Mariska Y. M., Boerma, Djamila, Huisman, Fokko W., van Ramshorst, Bert, van Dongen, Eric P. A., van den Anker, Johannes N., Knibbe, Catherijne A. J.
Materialtyp: Artigo
Språk:Inglês
Publicerad: Springer International Publishing 2016
Ämnen:
Original Research Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC4916199/
https://ncbi.nlm.nih.gov/pubmed/26818482
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s40262-015-0357-0
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