Higher Midazolam Clearance in Obese Adolescents Compared with Morbidly Obese Adults

BACKGROUND: The clearance of cytochrome P450 (CYP) 3A substrates is reported to be reduced with lower age, inflammation and obesity. As it is unknown what the overall influence is of these factors in the case of obese adolescents vs. morbidly obese adults, we studied covariates influencing the clear...

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Detalhes bibliográficos
Publicado no:Clin Pharmacokinet
Main Authors: van Rongen, Anne, Brill, Margreke J. E., Vaughns, Janelle D., Välitalo, Pyry A. J., van Dongen, Eric P. A., van Ramshorst, Bert, Barrett, Jeffrey S., van den Anker, Johannes N., Knibbe, Catherijne A. J.
Formato: Artigo
Idioma:Inglês
Publicado em: Springer International Publishing 2017
Assuntos:
Original Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5904241/
https://ncbi.nlm.nih.gov/pubmed/28785981
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s40262-017-0579-4
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