Higher Midazolam Clearance in Obese Adolescents Compared with Morbidly Obese Adults

BACKGROUND: The clearance of cytochrome P450 (CYP) 3A substrates is reported to be reduced with lower age, inflammation and obesity. As it is unknown what the overall influence is of these factors in the case of obese adolescents vs. morbidly obese adults, we studied covariates influencing the clear...

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Podrobná bibliografie
Vydáno v:Clin Pharmacokinet
Hlavní autoři: van Rongen, Anne, Brill, Margreke J. E., Vaughns, Janelle D., Välitalo, Pyry A. J., van Dongen, Eric P. A., van Ramshorst, Bert, Barrett, Jeffrey S., van den Anker, Johannes N., Knibbe, Catherijne A. J.
Médium: Artigo
Jazyk:Inglês
Vydáno: Springer International Publishing 2017
Témata:
Original Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5904241/
https://ncbi.nlm.nih.gov/pubmed/28785981
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s40262-017-0579-4
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