Higher Midazolam Clearance in Obese Adolescents Compared with Morbidly Obese Adults

BACKGROUND: The clearance of cytochrome P450 (CYP) 3A substrates is reported to be reduced with lower age, inflammation and obesity. As it is unknown what the overall influence is of these factors in the case of obese adolescents vs. morbidly obese adults, we studied covariates influencing the clear...

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Bibliographische Detailangaben
Veröffentlicht in:Clin Pharmacokinet
Hauptverfasser: van Rongen, Anne, Brill, Margreke J. E., Vaughns, Janelle D., Välitalo, Pyry A. J., van Dongen, Eric P. A., van Ramshorst, Bert, Barrett, Jeffrey S., van den Anker, Johannes N., Knibbe, Catherijne A. J.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Springer International Publishing 2017
Schlagworte:
Original Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5904241/
https://ncbi.nlm.nih.gov/pubmed/28785981
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s40262-017-0579-4
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