Population pharmacokinetics of midazolam and its metabolites in overweight and obese adolescents

AIM: In view of the increasing prevalence of obesity in adolescents, the aim of this study was to determine the pharmacokinetics of the CYP3A substrate midazolam and its metabolites in overweight and obese adolescents. METHODS: Overweight (BMI for age ≥ 85(th) percentile) and obese (BMI for age ≥ 95...

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Shranjeno v:
Bibliografske podrobnosti
izdano v:Br J Clin Pharmacol
Main Authors: van Rongen, Anne, Vaughns, Janelle D, Moorthy, Ganesh S, Barrett, Jeffrey S, Knibbe, Catherijne A J, van den Anker, Johannes N
Format: Artigo
Jezik:Inglês
Izdano: John Wiley & Sons, Ltd 2015
Teme:
Paediatric Clinical Pharmacology
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4631191/
https://ncbi.nlm.nih.gov/pubmed/26044579
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bcp.12693
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