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Population pharmacokinetics of midazolam and its metabolites in overweight and obese adolescents

AIM: In view of the increasing prevalence of obesity in adolescents, the aim of this study was to determine the pharmacokinetics of the CYP3A substrate midazolam and its metabolites in overweight and obese adolescents. METHODS: Overweight (BMI for age ≥ 85(th) percentile) and obese (BMI for age ≥ 95...

詳細記述

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書誌詳細
出版年:Br J Clin Pharmacol
主要な著者: van Rongen, Anne, Vaughns, Janelle D, Moorthy, Ganesh S, Barrett, Jeffrey S, Knibbe, Catherijne A J, van den Anker, Johannes N
フォーマット: Artigo
言語:Inglês
出版事項: John Wiley & Sons, Ltd 2015
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC4631191/
https://ncbi.nlm.nih.gov/pubmed/26044579
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bcp.12693
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