Increased Metformin Clearance in Overweight and Obese Adolescents: A Pharmacokinetic Substudy of a Randomized Controlled Trial

BACKGROUND: In view of the increased use of metformin in obese adolescents, the aim of this study was to determine the pharmacokinetics of metformin in overweight and obese adolescents. METHODS: In overweight and obese adolescents receiving metformin 500 or 1000 mg twice daily for 37 weeks during a...

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Bibliographic Details
Published in:Paediatr Drugs
Main Authors: van Rongen, Anne, van der Aa, Marloes P., Matic, Maja, van Schaik, Ron H. N., Deneer, Vera H. M., van der Vorst, Marja M., Knibbe, Catherijne A. J.
Format: Artigo
Language:Inglês
Published: Springer International Publishing 2018
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Original Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6028885/
https://ncbi.nlm.nih.gov/pubmed/29748932
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s40272-018-0293-1
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