Influence of Morbid Obesity on the Pharmacokinetics of Morphine, Morphine-3-Glucuronide, and Morphine-6-Glucuronide

INTRODUCTION: Obesity is associated with many pathophysiological changes that may result in altered drug metabolism. The aim of this study is to investigate the influence of obesity on the pharmacokinetics of morphine, morphine-3-glucuronide (M3G), and morphine-6-glucuronide (M6G) through a combined...

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Dettagli Bibliografici
Pubblicato in:Clin Pharmacokinet
Autori principali: de Hoogd, Sjoerd, Välitalo, Pyry A. J., Dahan, Albert, van Kralingen, Simone, Coughtrie, Michael M. W., van Dongen, Eric P. A., van Ramshorst, Bert, Knibbe, Catherijne A. J.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Springer International Publishing 2017
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Original Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5694499/
https://ncbi.nlm.nih.gov/pubmed/28510797
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s40262-017-0544-2
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