Influence of Seeding Density and Extracellular Matrix on Bile Acid Transport and Mrp4 Expression in Sandwich-Cultured Mouse Hepatocytes

por Swift, Brandon, Brouwer, Kim L.R.
Publicado 2010

Hepatocellular Exposure of Troglitazone Metabolites in Rat Sandwich-Cultured Hepatocytes Lacking Bcrp and Mrp2: Interplay between Formation and Excretion

por Yang, Kyunghee, Brouwer, Kim L. R.
Publicado 2014

Identification of Hepatic Phospholipidosis Inducers in Sandwich-Cultured Rat Hepatocytes, a Physiologically Relevant Model, Reveals Altered Basolateral Uptake and Biliary Excretion...

por Ferslew, Brian C., Brouwer, Kim L. R.
Publicado 2014

Use of Sandwich-Cultured Human Hepatocytes to Predict Biliary Clearance of Angiotensin II Receptor Blockers and HMG-CoA Reductase Inhibitors

por Abe, Koji, Bridges, Arlene S., Brouwer, Kim L. R.
Publicado 2009

Integration of Preclinical and Clinical Data with Pharmacokinetic Modeling and Simulation to Evaluate Fexofenadine as a Probe for Hepatobiliary Transport Function

por Swift, Brandon, Tian, Xianbin, Brouwer, Kim L. R.
Publicado 2009

Evaluation of (99m)Technetium-Mebrofenin and (99m)Technetium-Sestamibi as Specific Probes for Hepatic Transport Protein Function in Rat and Human Hepatocytes

por Swift, Brandon, Yue, Wei, Brouwer, Kim L. R.
Publicado 2010

Knocking Down Breast Cancer Resistance Protein (Bcrp) by Adenoviral Vector-Mediated RNA Interference (RNAi) in Sandwich-Cultured Rat Hepatocytes: A Novel Tool to Assess the Contrib...

por Yue, Wei, Abe, Koji, Brouwer, Kim L. R.
Publicado 2009

Mechanistic Modeling of the Hepatic Disposition of Estradiol-17β-Glucuronide in Sandwich-Cultured Human Hepatocytes

por Ito, Katsuaki, Sjöstedt, Noora, Brouwer, Kim L.R.
Publicado en Drug Metab Dispos (2020)

Physiologically-Based Pharmacokinetic (PBPK) Model of Morphine and Morphine-3-Glucuronide in Nonalcoholic Steatohepatitis (NASH)

por Sjöstedt, Noora, Neuhoff, Sibylle, Brouwer, Kim L.R.
Publicado en Clin Pharmacol Ther (2020)

Methods to Evaluate Biliary Excretion of Drugs in Humans: an Updated Review

por Ghibellini, Giulia, Leslie, Elaine M., Brouwer, Kim L.R.
Publicado 2006

Sandwich-Cultured Hepatocytes: An In Vitro Model to Evaluate Hepatobiliary Transporter-Based Drug Interactions and Hepatotoxicity

por Swift, Brandon, Pfeifer, Nathan D., Brouwer, Kim L.R.
Publicado 2010

Hepatic Basolateral Efflux Contributes Significantly to Rosuvastatin Disposition I: Characterization of Basolateral Versus Biliary Clearance Using a Novel Protocol in Sandwich-Cult...

por Pfeifer, Nathan D., Yang, Kyunghee, Brouwer, Kim L. R.
Publicado 2013

Effect of Liver Disease on Hepatic Transporter Expression and Function

por Thakkar, Nilay, Slizgi, Jason R., Brouwer, Kim L. R.
Publicado en J Pharm Sci (2017)

In Vitro Biliary Clearance of Angiotensin II Receptor Blockers and HMG-CoA Reductase Inhibitors in Sandwich-Cultured Rat Hepatocytes: Comparison to In Vivo Biliary Clearance

por Abe, Koji, Bridges, Arlene S., Yue, Wei, Brouwer, Kim L. R.
Publicado 2008

Sulindac and Its Metabolites Inhibit Multiple Transport Proteins in Rat and Human Hepatocytes

por Lee, Jin Kyung, Paine, Mary F., Brouwer, Kim L. R.
Publicado 2010

Effect of a Common Genetic Variant (p.V444A) in the Bile Salt Export Pump on the Inhibition of Bile Acid Transport by Cholestatic Medications

por Ali, Izna, Khalid, Seher, Stieger, Bruno, Brouwer, Kim L.R.
Publicado en Mol Pharm (2019)

Novel Insights into the Organic Solute Transporter Alpha/Beta, OSTα/β: From the Bench to the Bedside

por Beaudoin, James J., Brouwer, Kim L. R., Malinen, Melina M.
Publicado en Pharmacol Ther (2020)

Role of Multidrug Resistance–Associated Protein 4 in the Basolateral Efflux of Hepatically Derived Enalaprilat

por Ferslew, Brian C., Köck, Kathleen, Bridges, Arlene S., Brouwer, Kim L. R.
Publicado 2014

Species Differences in Hepatobiliary Disposition of Taurocholic Acid in Human and Rat Sandwich-Cultured Hepatocytes: Implications for Drug-Induced Liver Injury

por Yang, Kyunghee, Pfeifer, Nathan D., Köck, Kathleen, Brouwer, Kim L. R.
Publicado en J Pharmacol Exp Ther (2015)

Impact of reduced P‐glycoprotein function on digoxin concentrations in patients with dementia

por Ali, Izna, Guidone, Daniel, Nicolazzo, Joseph A., Brouwer, Kim L.R.
Publicado en Br J Clin Pharmacol (2019)