Cleavage of IgGs by proteases associated with invasive diseases: An evasion tactic against host immunity?

par Brezski, Randall J, Jordan, Robert E
Publié 2010

IgG Fc engineering to modulate antibody effector functions

par Wang, Xinhua, Mathieu, Mary, Brezski, Randall J.
Publié dans Protein Cell (2017)

The Origins, Specificity, and Potential Biological Relevance of Human Anti-IgG Hinge Autoantibodies

par Brezski, Randall J., Knight, David M., Jordan, Robert E.
Publié dans ScientificWorldJournal (2011)

The in vitro resistance of IgG2 to proteolytic attack concurs with a comparative paucity of autoantibodies against peptide analogs of the IgG2 hinge

par Brezski, Randall J, Oberholtzer, Allison, Strake, Brandy, Jordan, Robert E
Publié 2011

An Fc engineering approach that modulates antibody-dependent cytokine release without altering cell-killing functions

par Kinder, Michelle, Greenplate, Allison R, Strohl, William R, Jordan, Robert E, Brezski, Randall J
Publié dans MAbs (2015)

9th Annual European Antibody Congress, November 11–13, 2013, Geneva, Switzerland

par Reichert, Janice M, Beck, Alain, Lugovskoy, Alexey A, Wurch, Thierry, Coats, Steven, Brezski, Randall J
Publié dans MAbs (2014)

A single proteolytic cleavage within the lower hinge of trastuzumab reduces immune effector function and in vivo efficacy

par Fan, Xuejun, Brezski, Randall J, Fa, Ming, Deng, Hui, Oberholtzer, Allison, Gonzalez, Anneliese, Dubinsky, William P, Strohl, William R, Jordan, Robert E, Zhang, Ningyan, An, Zhiqiang
Publié 2012

Tumor-associated and microbial proteases compromise host IgG effector functions by a single cleavage proximal to the hinge

par Brezski, Randall J., Vafa, Omid, Petrone, Diane, Tam, Susan H., Powers, Gordon, Ryan, Mary H., Luongo, Jennifer L., Oberholtzer, Allison, Knight, David M., Jordan, Robert E.
Publié 2009

Domain-Specific Antibodies Reveal Differences in the Membrane Topologies of Apolipoprotein L1 in Serum and Podocytes

par Gupta, Nidhi, Wang, Xinhua, Wen, Xiaohui, Moran, Paul, Paluch, Maciej, Hass, Philip E., Heidersbach, Amy, Haley, Benjamin, Kirchhofer, Daniel, Brezski, Randall J., Peterson, Andrew S., Scales, Suzie J.
Publié dans J Am Soc Nephrol (2020)

Molecular characterization of human anti-hinge antibodies derived from single-cell cloning of normal human B cells

par Huang, Tao, Mathieu, Mary, Lee, Sophia, Wang, Xinhua, Kee, Yee Seir, Bevers, Jack J., Ciferri, Claudio, Estavez, Alberto, Wong, Manda, Chiang, Nancy Y., Nakamura, Gerald, Brezski, Randall J.
Publié dans J Biol Chem (2018)

A monoclonal antibody against hinge-cleaved IgG restores effector function to proteolytically-inactivated IgGs in vitro and in vivo

par Brezski, Randall J, Kinder, Michelle, Grugan, Katharine D, Soring, Keri L, Carton, Jill, Greenplate, Allison R, Petley, Theodore, Capaldi, Dorie, Brosnan, Kerry, Emmell, Eva, Watson, Sharon, Jordan, Robert E
Publié dans MAbs (2014)

FcRn binding is not sufficient for achieving systemic therapeutic levels of immunoglobulin G after oral delivery of enteric‐coated capsules in cynomolgus macaques

par Muzammil, Salman, Mabus, John R., Cooper, Philip R., Brezski, Randall J., Bement, Courtney B., Perkinson, Rob, Huebert, Norman D., Thompson, Suzanne, Levine, Dalia, Kliwinski, Connie, Bradley, Dino, Hornby, Pamela J.
Publié dans Pharmacol Res Perspect (2016)

Tonic B cell antigen receptor signals supply an NF-κB substrate for prosurvival BLyS signaling

par Stadanlick, Jason E, Kaileh, Mary, Karnell, Fredrick G, Scholz, Jean L, Miller, Juli P, Quinn, William J, Brezski, Randall J, Treml, Laura S, Jordan, Kimberly A, Monroe, John G, Sen, Ranjan, Cancro, Michael P
Publié 2008

Engineered Protease-resistant Antibodies with Selectable Cell-killing Functions

par Kinder, Michelle, Greenplate, Allison R., Grugan, Katharine D., Soring, Keri L., Heeringa, Katharine A., McCarthy, Stephen G., Bannish, Gregory, Perpetua, Meredith, Lynch, Frank, Jordan, Robert E., Strohl, William R., Brezski, Randall J.
Publié 2013

Effector-attenuating Substitutions That Maintain Antibody Stability and Reduce Toxicity in Mice

par Lo, Megan, Kim, Hok Seon, Tong, Raymond K., Bainbridge, Travis W., Vernes, Jean-Michel, Zhang, Yin, Lin, Yuwen Linda, Chung, Shan, Dennis, Mark S., Zuchero, Y. Joy Yu, Watts, Ryan J., Couch, Jessica A., Meng, Y. Gloria, Atwal, Jasvinder K., Brezski, Randall J., Spiess, Christoph, Ernst, James A.
Publié dans J Biol Chem (2017)

Tetravalent biepitopic targeting enables intrinsic antibody agonism of tumor necrosis factor receptor superfamily members

par Yang, Yanli, Yeh, Sherry H., Madireddi, Shravan, Matochko, Wadim L., Gu, Chen, Pacheco Sanchez, Patricia, Ultsch, Mark, De Leon Boenig, Gladys, Harris, Seth F., Leonard, Brandon, Scales, Suzie J., Zhu, Jing W., Christensen, Erin, Hang, Julie Q., Brezski, Randall J., Marsters, Scot, Ashkenazi, Avi, Sukumaran, Siddharth, Chiu, Henry, Cubas, Rafael, Kim, Jeong M., Lazar, Greg A.
Publié dans MAbs (2019)