A single proteolytic cleavage within the lower hinge of trastuzumab reduces immune effector function and in vivo efficacy

INTRODUCTION: Recent studies reported that human IgG antibodies are susceptible to specific proteolytic cleavage in their lower hinge region, and the hinge cleavage results in a loss of Fc-mediated effector functions. Trastuzumab is a humanized IgG(1 )therapeutic monoclonal antibody for the treatmen...

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Detalhes bibliográficos
Main Authors: Fan, Xuejun, Brezski, Randall J, Fa, Ming, Deng, Hui, Oberholtzer, Allison, Gonzalez, Anneliese, Dubinsky, William P, Strohl, William R, Jordan, Robert E, Zhang, Ningyan, An, Zhiqiang
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2012
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3680949/
https://ncbi.nlm.nih.gov/pubmed/22873525
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/bcr3240
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