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A monoclonal antibody against hinge-cleaved IgG restores effector function to proteolytically-inactivated IgGs in vitro and in vivo
We report a chimeric monoclonal antibody (mAb) directed to a neo-epitope that is exposed in the IgG lower hinge following proteolytic cleavage. The mAb, designated 2095–2, displays specificity for IdeS-generated F(ab’)(2) fragments, but not for full-length IgG or for closely-related F(ab’)(2) fragme...
Kaydedildi:
| Yayımlandı: | MAbs |
|---|---|
| Asıl Yazarlar: | , , , , , , , , , , , |
| Materyal Türü: | Artigo |
| Dil: | Inglês |
| Baskı/Yayın Bilgisi: |
Taylor & Francis
2014
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| Konular: | |
| Online Erişim: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4623506/ https://ncbi.nlm.nih.gov/pubmed/25517311 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/mabs.29825 |
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