A monoclonal antibody against hinge-cleaved IgG restores effector function to proteolytically-inactivated IgGs in vitro and in vivo

We report a chimeric monoclonal antibody (mAb) directed to a neo-epitope that is exposed in the IgG lower hinge following proteolytic cleavage. The mAb, designated 2095–2, displays specificity for IdeS-generated F(ab’)(2) fragments, but not for full-length IgG or for closely-related F(ab’)(2) fragme...

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Bibliografiske detaljer
Udgivet i:MAbs
Main Authors: Brezski, Randall J, Kinder, Michelle, Grugan, Katharine D, Soring, Keri L, Carton, Jill, Greenplate, Allison R, Petley, Theodore, Capaldi, Dorie, Brosnan, Kerry, Emmell, Eva, Watson, Sharon, Jordan, Robert E
Format: Artigo
Sprog:Inglês
Udgivet: Taylor & Francis 2014
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Reports
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4623506/
https://ncbi.nlm.nih.gov/pubmed/25517311
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/mabs.29825
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