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The in vitro resistance of IgG2 to proteolytic attack concurs with a comparative paucity of autoantibodies against peptide analogs of the IgG2 hinge

The mammalian antibody repertoire comprises immunoglobulin (Ig) molecules of multiple isotypes and subclasses with varying functional properties. Among the four subclasses of the human IgG isotype, we found that IgG2 exhibits a particular resistance to human and bacterial proteases that readily clea...

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Detalhes bibliográficos
Main Authors: Brezski, Randall J, Oberholtzer, Allison, Strake, Brandy, Jordan, Robert E
Formato: Artigo
Idioma:Inglês
Publicado em: Landes Bioscience 2011
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3242842/
https://ncbi.nlm.nih.gov/pubmed/22123056
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/mabs.3.6.18119
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