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The in vitro resistance of IgG2 to proteolytic attack concurs with a comparative paucity of autoantibodies against peptide analogs of the IgG2 hinge

The mammalian antibody repertoire comprises immunoglobulin (Ig) molecules of multiple isotypes and subclasses with varying functional properties. Among the four subclasses of the human IgG isotype, we found that IgG2 exhibits a particular resistance to human and bacterial proteases that readily clea...

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Bibliografiske detaljer
Main Authors: Brezski, Randall J, Oberholtzer, Allison, Strake, Brandy, Jordan, Robert E
Format: Artigo
Sprog:Inglês
Udgivet: Landes Bioscience 2011
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3242842/
https://ncbi.nlm.nih.gov/pubmed/22123056
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/mabs.3.6.18119
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