Cleavage of IgGs by proteases associated with invasive diseases: An evasion tactic against host immunity?

Por Brezski, Randall J, Jordan, Robert E
Publicado em 2010

Tumor evasion of humoral immunity mediated by proteolytic impairment of antibody triggered immune effector function

Por Zhang, Ningyan, Jordan, Robert E., An, Zhiqiang
Publicado no Oncoimmunology (2015)

The Origins, Specificity, and Potential Biological Relevance of Human Anti-IgG Hinge Autoantibodies

Por Brezski, Randall J., Knight, David M., Jordan, Robert E.
Publicado no ScientificWorldJournal (2011)

The in vitro resistance of IgG2 to proteolytic attack concurs with a comparative paucity of autoantibodies against peptide analogs of the IgG2 hinge

Por Brezski, Randall J, Oberholtzer, Allison, Strake, Brandy, Jordan, Robert E
Publicado em 2011

Proteinase-nicked IgGs: an unanticipated target for tumor immunotherapy

Por Jordan, Robert E., Fan, Xuejun, Salazar, Georgina, Zhang, Ningyan, An, Zhiqiang
Publicado no Oncoimmunology (2018)

Proteolytic single hinge cleavage of pertuzumab impairs its Fc effector function and antitumor activity in vitro and in vivo

Por Hsiao, Hao-Ching, Fan, Xuejun, Jordan, Robert E., Zhang, Ningyan, An, Zhiqiang
Publicado no Breast Cancer Res (2018)

An Fc engineering approach that modulates antibody-dependent cytokine release without altering cell-killing functions

Por Kinder, Michelle, Greenplate, Allison R, Strohl, William R, Jordan, Robert E, Brezski, Randall J
Publicado no MAbs (2015)

A single proteolytic cleavage within the lower hinge of trastuzumab reduces immune effector function and in vivo efficacy

Por Fan, Xuejun, Brezski, Randall J, Fa, Ming, Deng, Hui, Oberholtzer, Allison, Gonzalez, Anneliese, Dubinsky, William P, Strohl, William R, Jordan, Robert E, Zhang, Ningyan, An, Zhiqiang
Publicado em 2012

Tumor-associated and microbial proteases compromise host IgG effector functions by a single cleavage proximal to the hinge

Por Brezski, Randall J., Vafa, Omid, Petrone, Diane, Tam, Susan H., Powers, Gordon, Ryan, Mary H., Luongo, Jennifer L., Oberholtzer, Allison, Knight, David M., Jordan, Robert E.
Publicado em 2009

A monoclonal antibody against hinge-cleaved IgG restores effector function to proteolytically-inactivated IgGs in vitro and in vivo

Por Brezski, Randall J, Kinder, Michelle, Grugan, Katharine D, Soring, Keri L, Carton, Jill, Greenplate, Allison R, Petley, Theodore, Capaldi, Dorie, Brosnan, Kerry, Emmell, Eva, Watson, Sharon, Jordan, Robert E
Publicado no MAbs (2014)

Engineered Protease-resistant Antibodies with Selectable Cell-killing Functions

Por Kinder, Michelle, Greenplate, Allison R., Grugan, Katharine D., Soring, Keri L., Heeringa, Katharine A., McCarthy, Stephen G., Bannish, Gregory, Perpetua, Meredith, Lynch, Frank, Jordan, Robert E., Strohl, William R., Brezski, Randall J.
Publicado em 2013