Proteolytic single hinge cleavage of pertuzumab impairs its Fc effector function and antitumor activity in vitro and in vivo

BACKGROUND: Proteolytic impairment of the Fc effector functions of therapeutic monoclonal antibodies (mAbs) can compromise their antitumor efficacy in the tumor microenvironment and may represent an unappreciated mechanism of host immune evasion. Pertuzumab is a human epidermal growth factor recepto...

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Vydáno v:Breast Cancer Res
Hlavní autoři: Hsiao, Hao-Ching, Fan, Xuejun, Jordan, Robert E., Zhang, Ningyan, An, Zhiqiang
Médium: Artigo
Jazyk:Inglês
Vydáno: BioMed Central 2018
Témata:
Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5984793/
https://ncbi.nlm.nih.gov/pubmed/29859099
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13058-018-0972-4
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