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Tumor-associated and microbial proteases compromise host IgG effector functions by a single cleavage proximal to the hinge

The successful elimination of pathogenic cells and microorganisms by the humoral immune system relies on effective interactions between host immunoglobulins and Fcγ receptors on effector cells, in addition to the complement system. Essential Ig motifs that direct those interactions reside within the...

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Autors principals: Brezski, Randall J., Vafa, Omid, Petrone, Diane, Tam, Susan H., Powers, Gordon, Ryan, Mary H., Luongo, Jennifer L., Oberholtzer, Allison, Knight, David M., Jordan, Robert E.
Format: Artigo
Idioma:Inglês
Publicat: National Academy of Sciences 2009
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2758810/
https://ncbi.nlm.nih.gov/pubmed/19815504
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0904174106
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