A single proteolytic cleavage within the lower hinge of trastuzumab reduces immune effector function and in vivo efficacy

Lignende værker

• Proteolytic single hinge cleavage of pertuzumab impairs its Fc effector function and antitumor activity in vitro and in vivo
  af: Hsiao, Hao-Ching, et al.
  Udgivet: (2018)
• The in vitro resistance of IgG2 to proteolytic attack concurs with a comparative paucity of autoantibodies against peptide analogs of the IgG2 hinge
  af: Brezski, Randall J, et al.
  Udgivet: (2011)
• Tumor-associated and microbial proteases compromise host IgG effector functions by a single cleavage proximal to the hinge
  af: Brezski, Randall J., et al.
  Udgivet: (2009)
• Tumor evasion of humoral immunity mediated by proteolytic impairment of antibody triggered immune effector function
  af: Zhang, Ningyan, et al.
  Udgivet: (2015)
• A monoclonal antibody against hinge-cleaved IgG restores effector function to proteolytically-inactivated IgGs in vitro and in vivo
  af: Brezski, Randall J, et al.
  Udgivet: (2014)