Regulatory Role of mTOR Signaling in Exosome Secretion and Osteogenic Changes in Smooth Muscle Cells Lacking Acid Ceramidase Gene

por Bhat, Owais M., Yuan, Xinxu, Kukreja, Rakesh C., Li, Pin-Lan
Publicado en FASEB J (2021)

Differential effects of short chain fatty acids on endothelial Nlrp3 inflammasome activation and neointima formation: Antioxidant action of butyrate

por Yuan, Xinxu, Wang, Lei, Bhat, Owais M., Lohner, Hannah, Li, Pin-Lan
Publicado en Redox Biol (2018)

Protective Role of Autophagy in Nlrp3 Inflammasome Activation and Medial Thickening of Mouse Coronary Arteries

por Yuan, Xinxu, Bhat, Owais M., Meng, Nan, Lohner, Hannah, Li, Pin-Lan
Publicado en Am J Pathol (2018)

Endothelial Acid Ceramidase in Exosome-Mediated Release of NLRP3 Inflammasome Products during Hyperglycemia: Evidence from Endothelium-Specific Deletion of Asah1 Gene

por Yuan, Xinxu, Bhat, Owais M., Lohner, Hannah, Zhang, Yang, Li, Pin-Lan
Publicado en Biochim Biophys Acta Mol Cell Biol Lipids (2019)

Downregulation of Lysosomal Acid Ceramidase Mediates HMGB1-Induced Migration and Proliferation of Mouse Coronary Arterial Myocytes

por Yuan, Xinxu, Bhat, Owais M., Lohner, Hannah, Zhang, Yang, Li, Pin-Lan
Publicado en Front Cell Dev Biol (2020)

Sphingolipids and Redox Signaling in Renal Regulation and Chronic Kidney Diseases

por Bhat, Owais M., Yuan, Xinxu, Li, Guangbi, Lee, RaMi, Li, Pin-Lan
Publicado en Antioxid Redox Signal (2018)

Medial calcification in the arterial wall of smooth muscle cell‐specific Smpd1 transgenic mice: A ceramide‐mediated vasculopathy

por Bhat, Owais M., Yuan, Xinxu, Cain, Chad, Salloum, Fadi N., Li, Pin‐Lan
Publicado en J Cell Mol Med (2019)

Abnormal Lysosomal Positioning and Small Extracellular Vesicle Secretion in Arterial Stiffening and Calcification of Mice Lacking Mucolipin 1 Gene

por Bhat, Owais M., Yuan, Xinxu, Camus, Sarah, Salloum, Fadi N., Li, Pin-Lan
Publicado en Int J Mol Sci (2020)

Inhibitory effects of growth differentiation factor 11 on autophagy deficiency-induced dedifferentiation of arterial smooth muscle cells

por Yuan, Xinxu, Bhat, Owais M., Lohner, Hannah, Li, Ningjun, Zhang, Yang, Li, Pin-Lan
Publicado en Am J Physiol Heart Circ Physiol (2019)

Control of lysosomal TRPML1 channel activity and exosome release by acid ceramidase in mouse podocytes

por Li, Guangbi, Huang, Dandan, Hong, Jinni, Bhat, Owais M., Yuan, Xinxu, Li, Pin-Lan
Publicado en Am J Physiol Cell Physiol (2019)

Reversal of Endothelial Extracellular Vesicle-Induced Smooth Muscle Phenotype Transition by Hypercholesterolemia Stimulation: Role of NLRP3 Inflammasome Activation

por Yuan, Xinxu, Bhat, Owais M., Samidurai, Arun, Das, Anindita, Zhang, Yang, Li, Pin-Lan
Publicado en Front Cell Dev Biol (2020)

Suppression of Glucagon-Like Peptide-1 Release by Inhibition of Intestinal NLRP3 Inflammasome Activation in Asc(–/–) and Nlrp3(–/–) Mice

por Chen, Yu, Kidd, Jason, Bhat, Owais M., Yuan, Xinxu, Hong, Jinni, He, Xingxiang, Li, Pin-Lan
Publicado en Front Physiol (2019)

Endothelial NLRP3 inflammasome activation and arterial neointima formation associated with acid sphingomyelinase during hypercholesterolemia

por Koka, Saisudha, Xia, Min, Chen, Yang, Bhat, Owais M., Yuan, Xinxu, Boini, Krishna M., Li, Pin-Lan
Publicado en Redox Biol (2017)

Arterial Medial Calcification through Enhanced small Extracellular Vesicle Release in Smooth Muscle-Specific Asah1 Gene Knockout Mice

por Bhat, Owais M., Li, Guangbi, Yuan, Xinxu, Huang, Dandan, Gulbins, Erich, Kukreja, Rakesh C., Li, Pin-Lan
Publicado en Sci Rep (2020)

Contribution of Podocyte Inflammatory Exosome Release to Glomerular Inflammation and Sclerosis during Hyperhomocysteinemia

por Huang, Dandan, Li, Guangbi, Zhang, Qinghua, Bhat, Owais M., Zou, Yao, Ritter, Joseph K., Li, Pin-Lan
Publicado en Biochim Biophys Acta Mol Basis Dis (2021)

Release and Actions of Inflammatory Exosomes in Pulmonary Emphysema: Potential Therapeutic Target of Acupuncture

por Zou, Yao, Bhat, Owais M, Yuan, Xinxu, Li, Guangbi, Huang, Dandan, Guo, Yi, Zhou, Dan, Li, Pin-Lan
Publicado en J Inflamm Res (2021)

Lysosomal regulation of extracellular vesicle excretion during D-ribose-induced NLRP3 inflammasome activation in podocytes

por Hong, Jinni, Bhat, Owais M., Li, Guangbi, Dempsey, Sara K., Zhang, Qinghua, Ritter, Joseph K., Li, Weiwei, Li, Pin-Lan
Publicado en Biochim Biophys Acta Mol Cell Res (2019)

NLRP3 inflammasome as a novel target for docosahexaenoic acid metabolites to abrogate glomerular injury

por Li, Guangbi, Chen, Zhida, Bhat, Owais M., Zhang, Qinghua, Abais-Battad, Justine M., Conley, Sabena M., Ritter, Joseph K., Li, Pin-Lan
Publicado en J Lipid Res (2017)

Abnormal podocyte TRPML1 channel activity and exosome release in mice with podocyte-specific Asah1 gene deletion

por Li, Guangbi, Huang, Dandan, Bhat, Owais M., Poklis, Justin L., Zhang, Aolin, Zou, Yao, Kidd, Jason, Gehr, Todd W.B., Li, Pin-Lan
Publicado en Biochim Biophys Acta Mol Cell Biol Lipids (2020)

Podocytopathy and Nephrotic Syndrome in Mice with Podocyte-Specific Deletion of the Asah1 Gene: Role of Ceramide Accumulation in Glomeruli

por Li, Guangbi, Kidd, Jason, Kaspar, Cristin, Dempsey, Sara, Bhat, Owais M., Camus, Sarah, Ritter, Joseph K., Gehr, Todd W.B., Gulbins, Erich, Li, Pin-Lan
Publicado en Am J Pathol (2020)