Abnormal podocyte TRPML1 channel activity and exosome release in mice with podocyte-specific Asah1 gene deletion

Podocytopathy and associated nephrotic syndrome (NS) have been reported in a knockout mouse strain (Asah1(fl/fl)/Podo(Cre)) with a podocyte-specific deletion of α subunit (the main catalytic subunit) of acid ceramidase (Ac). However, the pathogenesis of podocytopathy of these mice remains unknown. T...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Biochim Biophys Acta Mol Cell Biol Lipids
Prif Awduron: Li, Guangbi, Huang, Dandan, Bhat, Owais M., Poklis, Justin L., Zhang, Aolin, Zou, Yao, Kidd, Jason, Gehr, Todd W.B., Li, Pin-Lan
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: 2020
Pynciau:
Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC7770122/
https://ncbi.nlm.nih.gov/pubmed/33221496
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbalip.2020.158856
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