Podocytopathy and Nephrotic Syndrome in Mice with Podocyte-Specific Deletion of the Asah1 Gene: Role of Ceramide Accumulation in Glomeruli

Lysosomal acid ceramidase (Ac) has been shown to be critical for ceramide hydrolysis and regulation of lysosome function and cellular homeostasis. In the present study, we generated a knockout mouse strain (Asah1(fl/fl)/Podo(Cre)) with a podocyte-specific deletion of the α subunit (main catalytic su...

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Publicado no:Am J Pathol
Main Authors: Li, Guangbi, Kidd, Jason, Kaspar, Cristin, Dempsey, Sara, Bhat, Owais M., Camus, Sarah, Ritter, Joseph K., Gehr, Todd W.B., Gulbins, Erich, Li, Pin-Lan
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Investigative Pathology 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7280759/
https://ncbi.nlm.nih.gov/pubmed/32194052
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ajpath.2020.02.008
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