Structural Basis for Dual Nucleotide Selectivity of Aminoglycoside 2″-Phosphotransferase IVa Provides Insight on Determinants of Nucleotide Specificity of Aminoglycoside Kinases

por Shi, Kun, Berghuis, Albert M.
Publicado em 2012

Substrate promiscuity of an aminoglycoside antibiotic resistance enzyme via target mimicry

por Fong, Desiree H., Berghuis, Albert M.
Publicado em 2002

Structural Basis of APH(3′)-IIIa-Mediated Resistance to N1-Substituted Aminoglycoside Antibiotics

por Fong, Desiree H., Berghuis, Albert M.
Publicado em 2009

Small-Angle X-Ray Scattering Analysis of the Bifunctional Antibiotic Resistance Enzyme Aminoglycoside (6′) Acetyltransferase-Ie/Aminoglycoside (2″) Phosphotransferase-Ia Reveals a...

por Caldwell, Shane J., Berghuis, Albert M.
Publicado em 2012

Plasticity of Aminoglycoside Binding to Antibiotic Kinase APH(2″)-Ia

por Caldwell, Shane J., Berghuis, Albert M.
Publicado no Antimicrob Agents Chemother (2018)

Look and Outlook on Enzyme-Mediated Macrolide Resistance

por Golkar, Tolou, Zieliński, Michał, Berghuis, Albert M.
Publicado no Front Microbiol (2018)

Structural and functional insights into esterase-mediated macrolide resistance

por Zieliński, Michał, Park, Jaeok, Sleno, Barry, Berghuis, Albert M.
Publicado no Nat Commun (2021)

Crystal Structures of Two Aminoglycoside Kinases Bound with a Eukaryotic Protein Kinase Inhibitor

por Fong, Desiree H., Xiong, Bing, Hwang, Jiyoung, Berghuis, Albert M.
Publicado em 2011

Structure of human farnesyl pyrophosphate synthase in complex with an aminopyridine bisphosphonate and two molecules of inorganic phosphate

por Park, Jaeok, Lin, Yih-Shyan, Tsantrizos, Youla S., Berghuis, Albert M.
Publicado em 2014

Human isoprenoid synthase enzymes as therapeutic targets

por Park, Jaeok, Matralis, Alexios N., Berghuis, Albert M., Tsantrizos, Youla S.
Publicado em 2014

Towards a better understanding of the substrate specificity of the UDP-N-acetylglucosamine C4 epimerase WbpP

por Demendi, Melinda, Ishiyama, Noboru, Lam, Joseph S., Berghuis, Albert M., Creuzenet, Carole
Publicado em 2005

Structural basis for streptogramin B resistance in Staphylococcus aureus by virginiamycin B lyase

por Korczynska, Magdalena, Mukhtar, Tariq A., Wright, Gerard D., Berghuis, Albert M.
Publicado em 2007

Prospects for circumventing aminoglycoside kinase mediated antibiotic resistance

por Shi, Kun, Caldwell, Shane J., Fong, Desiree H., Berghuis, Albert M.
Publicado em 2013

Human farnesyl pyrophosphate synthase is allosterically inhibited by its own product

por Park, Jaeok, Zielinski, Michal, Magder, Alexandr, Tsantrizos, Youla S., Berghuis, Albert M.
Publicado no Nat Commun (2017)

Phosphonate and Bisphosphonate Inhibitors of Farnesyl Pyrophosphate Synthases: A Structure-Guided Perspective

por Park, Jaeok, Pandya, Vishal R., Ezekiel, Sean J., Berghuis, Albert M.
Publicado no Front Chem (2021)

Crystallization and preliminary crystallographic analysis of an aminoglycoside kinase from Legionella pneumophila

por Lemke, Christopher T., Hwang, Jiyoung, Xiong, Bing, Cianciotto, Nicholas P., Berghuis, Albert M.
Publicado em 2005

X-ray structure of the AAC(6′)-Ii antibiotic resistance enzyme at 1.8 Å resolution; examination of oligomeric arrangements in GNAT superfamily members

por Burk, David L., Ghuman, Navleen, Wybenga-Groot, Leanne E., Berghuis, Albert M.
Publicado em 2003

Structure of the Antibiotic Resistance Factor Spectinomycin Phosphotransferase from Legionella pneumophila

por Fong, Desiree H., Lemke, Christopher T., Hwang, Jiyoung, Xiong, Bing, Berghuis, Albert M.
Publicado em 2010

Effect of solvent and protein dynamics in ligand recognition and inhibition of aminoglycoside adenyltransferase 2″‐Ia

por Bacot‐Davis, Valjean R., Bassenden, Angelia V., Sprules, Tara, Berghuis, Albert M.
Publicado no Protein Sci (2017)

Ternary complex structures of human farnesyl pyrophosphate synthase bound with a novel inhibitor and secondary ligands provide insights into the molecular details of the enzyme’s a...

por Park, Jaeok, Lin, Yih-Shyan, De Schutter, Joris W, Tsantrizos, Youla S, Berghuis, Albert M
Publicado em 2012