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Plasticity of Aminoglycoside Binding to Antibiotic Kinase APH(2″)-Ia
The APH(2″)-Ia aminoglycoside resistance enzyme forms the C-terminal domain of the bifunctional AAC(6′)-Ie/APH(2″)-Ia enzyme and confers high-level resistance to natural 4,6-disubstituted aminoglycosides. In addition, reports have suggested that the enzyme can phosphorylate 4,5-disubstituted compoun...
Shranjeno v:
| izdano v: | Antimicrob Agents Chemother |
|---|---|
| Main Authors: | , |
| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
American Society for Microbiology
2018
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| Teme: | |
| Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6021647/ https://ncbi.nlm.nih.gov/pubmed/29661878 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00202-18 |
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