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Mutations in the aph(2")-Ic Gene Are Responsible for Increased Levels of Aminoglycoside Resistance
Random PCR mutagenesis of the enterococcal aph(2")-Ic gene followed by selection for mutant enzymes that confer enhanced levels of aminoglycoside resistance resulted in mutants of APH(2")-Ic with His-258-Leu and Phe-108-Leu substitutions, all of which conferred rises in the MICs of several...
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| Autori principali: | , , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
American Society for Microbiology
2002
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC128768/ https://ncbi.nlm.nih.gov/pubmed/12234853 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.46.10.3253-3256.2002 |
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