Mutations in the aph(2")-Ic Gene Are Responsible for Increased Levels of Aminoglycoside Resistance

Random PCR mutagenesis of the enterococcal aph(2")-Ic gene followed by selection for mutant enzymes that confer enhanced levels of aminoglycoside resistance resulted in mutants of APH(2")-Ic with His-258-Leu and Phe-108-Leu substitutions, all of which conferred rises in the MICs of several aminoglyc...

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Publié dans:	Antimicrob Agents Chemother
Auteurs principaux:	Lee, Hae Kyung, Vakulenko, Sergei B., Clewell, Don B., Lerner, Stephen A., Chow, Joseph W.
Format:	Artigo
Langue:	Inglês
Publié:	American Society for Microbiology (ASM) 2002
Sujets:	Mechanisms of Resistance
Accès en ligne:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC128768/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12234853/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/AAC.46.10.3253-3256.2002
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