Mutations in the aph(2")-Ic Gene Are Responsible for Increased Levels of Aminoglycoside Resistance

Random PCR mutagenesis of the enterococcal aph(2")-Ic gene followed by selection for mutant enzymes that confer enhanced levels of aminoglycoside resistance resulted in mutants of APH(2")-Ic with His-258-Leu and Phe-108-Leu substitutions, all of which conferred rises in the MICs of several...

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Main Authors: Lee, Hae Kyung, Vakulenko, Sergei B., Clewell, Don B., Lerner, Stephen A., Chow, Joseph W.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology 2002
Fag:
Mechanisms of Resistance
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC128768/
https://ncbi.nlm.nih.gov/pubmed/12234853
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.46.10.3253-3256.2002
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