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Crystal Structures of Two Aminoglycoside Kinases Bound with a Eukaryotic Protein Kinase Inhibitor

Antibiotic resistance is recognized as a growing healthcare problem. To address this issue, one strategy is to thwart the causal mechanism using an adjuvant in partner with the antibiotic. Aminoglycosides are a class of clinically important antibiotics used for the treatment of serious infections. T...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Fong, Desiree H., Xiong, Bing, Hwang, Jiyoung, Berghuis, Albert M.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Public Library of Science 2011
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3090406/
https://ncbi.nlm.nih.gov/pubmed/21573013
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0019589
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