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Crystallization and preliminary crystallographic analysis of an aminoglycoside kinase from Legionella pneumophila

9-Aminoglycoside phosphotransferase type Ia [APH(9)-Ia] is a resistance factor in Legionella pneuemophila, the causative agent of legionnaires’ disease. It is responsible for providing intrinsic resistance to the antibiotic spectinomycin. APH(9)-Ia phosphorylates one of the hydroxyl moieties of spec...

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Main Authors: Lemke, Christopher T., Hwang, Jiyoung, Xiong, Bing, Cianciotto, Nicholas P., Berghuis, Albert M.
Format: Artigo
Jezik:Inglês
Izdano: International Union of Crystallography 2005
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC1952339/
https://ncbi.nlm.nih.gov/pubmed/16511108
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1107/S1744309105016301
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