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Human farnesyl pyrophosphate synthase is allosterically inhibited by its own product

Farnesyl pyrophosphate synthase (FPPS) is an enzyme of the mevalonate pathway and a well-established therapeutic target. Recent research has focused around a newly identified druggable pocket near the enzyme's active site. Pharmacological exploitation of this pocket is deemed promising; however...

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Bibliografiset tiedot
Julkaisussa:Nat Commun
Päätekijät: Park, Jaeok, Zielinski, Michal, Magder, Alexandr, Tsantrizos, Youla S., Berghuis, Albert M.
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: Nature Publishing Group 2017
Aiheet:
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC5253651/
https://ncbi.nlm.nih.gov/pubmed/28098152
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms14132
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