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Human farnesyl pyrophosphate synthase is allosterically inhibited by its own product
Farnesyl pyrophosphate synthase (FPPS) is an enzyme of the mevalonate pathway and a well-established therapeutic target. Recent research has focused around a newly identified druggable pocket near the enzyme's active site. Pharmacological exploitation of this pocket is deemed promising; however...
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| Опубликовано в: : | Nat Commun |
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| Главные авторы: | , , , , |
| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
Nature Publishing Group
2017
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5253651/ https://ncbi.nlm.nih.gov/pubmed/28098152 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms14132 |
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