Crystallographic and thermodynamic characterization of phenylaminopyridine bisphosphonates binding to human farnesyl pyrophosphate synthase

Human farnesyl pyrophosphate synthase (hFPPS) catalyzes the production of the 15-carbon isoprenoid farnesyl pyrophosphate. The enzyme is a key regulator of the mevalonate pathway and a well-established drug target. Notably, it was elucidated as the molecular target of nitrogen-containing bisphosphon...

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Udgivet i:PLoS One
Main Authors: Park, Jaeok, Rodionov, Dmitry, De Schutter, Joris W., Lin, Yih-Shyan, Tsantrizos, Youla S., Berghuis, Albert M.
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2017
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5643135/
https://ncbi.nlm.nih.gov/pubmed/29036218
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0186447
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