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Crystallographic and thermodynamic characterization of phenylaminopyridine bisphosphonates binding to human farnesyl pyrophosphate synthase

Human farnesyl pyrophosphate synthase (hFPPS) catalyzes the production of the 15-carbon isoprenoid farnesyl pyrophosphate. The enzyme is a key regulator of the mevalonate pathway and a well-established drug target. Notably, it was elucidated as the molecular target of nitrogen-containing bisphosphon...

詳細記述

保存先:
書誌詳細
出版年:PLoS One
主要な著者: Park, Jaeok, Rodionov, Dmitry, De Schutter, Joris W., Lin, Yih-Shyan, Tsantrizos, Youla S., Berghuis, Albert M.
フォーマット: Artigo
言語:Inglês
出版事項: Public Library of Science 2017
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC5643135/
https://ncbi.nlm.nih.gov/pubmed/29036218
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0186447
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