Structure of human farnesyl pyrophosphate synthase in complex with an aminopyridine bisphosphonate and two molecules of inorganic phosphate

Human farnesyl pyrophosphate synthase (hFPPS) produces farnesyl pyrophos­phate, an isoprenoid essential for a variety of cellular processes. The enzyme has been well established as the molecular target of the nitrogen-containing bisphosphonates (N-BPs), which are best known for their antiresorptive...

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Bibliografiska uppgifter
Huvudupphovsmän: Park, Jaeok, Lin, Yih-Shyan, Tsantrizos, Youla S., Berghuis, Albert M.
Materialtyp: Artigo
Språk:Inglês
Publicerad: International Union of Crystallography 2014
Ämnen:
Structural Communications
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC3944689/
https://ncbi.nlm.nih.gov/pubmed/24598914
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1107/S2053230X14002106
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