Molecular mechanisms of Sonic hedgehog mutant effects in holoprosencephaly

Por Maity, Tapan, Fuse, Naoyuki, Beachy, Philip A.
Publicado em 2005

Gli2 trafficking links Hedgehog-dependent activation of Smoothened in the primary cilium to transcriptional activation in the nucleus

Por Kim, Jynho, Kato, Masaki, Beachy, Philip A.
Publicado em 2009

The stromal niche for epithelial stem cells: a template for regeneration and a brake on malignancy

Por Roberts, Kelsey J., Kershner, Aaron M., Beachy, Philip A.
Publicado no Cancer Cell (2017)

Genetic and biochemical definition of the Hedgehog receptor

Por Zheng, Xiaoyan, Mann, Randall K., Sever, Navdar, Beachy, Philip A.
Publicado em 2010

Axon Targeting of Olfactory Receptor Neurons is Patterned by Coupled Hedgehog Signaling at Two Distinct Steps

Por Chou, Ya-Hui, Zheng, Xiaoyan, Beachy, Philip A., Luo, Liqun
Publicado em 2010

Inhibition of Hedgehog signaling by direct binding of cyclopamine to Smoothened

Por Chen, James K., Taipale, Jussi, Cooper, Michael K., Beachy, Philip A.
Publicado em 2002

Spatially restricted Hedgehog signaling regulates HGF-induced branching of the adult prostate

Por Lim, Agnes, Shin, Kunyoo, Zhao, Chen, Kawano, Sally, Beachy, Philip A.
Publicado no Nat Cell Biol (2014)

A Comparison of Ci/Gli Activity as Regulated by Sufu in Drosophila and Mammalian Hedgehog Response

Por Oh, Sekyung, Kato, Masaki, Zhang, Chi, Guo, Yurong, Beachy, Philip A.
Publicado no PLoS One (2015)

Extensive phosphorylation of Smoothened in Hedgehog pathway activation

Por Zhang, Chi, Williams, Elizabeth H., Guo, Yurong, Lum, Lawrence, Beachy, Philip A.
Publicado em 2004

Arsenic antagonizes the Hedgehog pathway by preventing ciliary accumulation and reducing stability of the Gli2 transcriptional effector

Por Kim, Jynho, Lee, John J., Kim, James, Gardner, Dale, Beachy, Philip A.
Publicado em 2010

Small molecule modulation of Smoothened activity

Por Chen, James K., Taipale, Jussi, Young, Keith E., Maiti, Tapan, Beachy, Philip A.
Publicado em 2002

A genomewide screen for components of the RNAi pathway in Drosophila cultured cells

Por Dorner, Silke, Lum, Lawrence, Kim, Michelle, Paro, Renato, Beachy, Philip A., Green, Rachel
Publicado em 2006

Bifurcating action of Smoothened in Hedgehog signaling is mediated by Dlg5

Por Chong, Yong Chun, Mann, Randall K., Zhao, Chen, Kato, Masaki, Beachy, Philip A.
Publicado no Genes Dev (2015)

Rapid, direct activity assays for Smoothened reveal Hedgehog pathway regulation by membrane cholesterol and extracellular sodium

Por Myers, Benjamin R., Neahring, Lila, Zhang, Yunxiao, Roberts, Kelsey J., Beachy, Philip A.
Publicado no Proc Natl Acad Sci U S A (2017)

Interactions between Hedgehog proteins and their binding partners come into view

Por Beachy, Philip A., Hymowitz, Sarah G., Lazarus, Robert A., Leahy, Daniel J., Siebold, Christian
Publicado em 2010

The mode of Hedgehog binding to Ihog homologs is not conserved across different phyla

Por McLellan, Jason S., Zheng, Xiaoyan, Hauk, Glenn, Ghirlando, Rodolfo, Beachy, Philip A., Leahy, Daniel J.
Publicado em 2008

Structure of the protein core of the glypican Dally-like and localization of a region important for hedgehog signaling

Por Kim, Min-Sung, Saunders, Adam M., Hamaoka, Brent Y., Beachy, Philip A., Leahy, Daniel J.
Publicado em 2011

Simultaneous Measurement of Smoothened Entry Into and Exit From the Primary Cilium

Por Kim, Jynho, Hsia, Elaine Y. C., Kim, James, Sever, Navdar, Beachy, Philip A., Zheng, Xiaoyan
Publicado em 2014

The role of ciliary trafficking in Hedgehog receptor signaling

Por Kim, Jynho, Hsia, Elaine Y. C., Brigui, Amira, Plessis, Anne, Beachy, Philip A., Zheng, Xiaoyan
Publicado no Sci Signal (2015)

Scube/You activity mediates release of dually lipid-modified Hedgehog signal in soluble form

Por Creanga, Adrian, Glenn, Thomas D., Mann, Randall K., Saunders, Adam M., Talbot, William S., Beachy, Philip A.
Publicado em 2012