Inhibition of Hedgehog signaling by direct binding of cyclopamine to Smoothened

The steroidal alkaloid cyclopamine has both teratogenic and antitumor activities arising from its ability to specifically block cellular responses to vertebrate Hedgehog signaling. We show here, using photoaffinity and fluorescent derivatives, that this inhibitory effect is mediated by direct bindin...

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Dades bibliogràfiques

Publicat a:	Genes Dev
Autors principals:	Chen, James K., Taipale, Jussi, Cooper, Michael K., Beachy, Philip A.
Format:	Artigo
Idioma:	Inglês
Publicat:	Cold Spring Harbor Laboratory Press 2002
Matèries:	Research Communication
Accés en línia:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC187469/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12414725/ https://ncbi.nlm.nih.govhttps://doi.org/10.1101/gad.1025302
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