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Inhibition of Hedgehog signaling by direct binding of cyclopamine to Smoothened
The steroidal alkaloid cyclopamine has both teratogenic and antitumor activities arising from its ability to specifically block cellular responses to vertebrate Hedgehog signaling. We show here, using photoaffinity and fluorescent derivatives, that this inhibitory effect is mediated by direct bindin...
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| 主要な著者: | , , , |
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| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
Cold Spring Harbor Laboratory Press
2002
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC187469/ https://ncbi.nlm.nih.gov/pubmed/12414725 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.1025302 |
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