Inhibition of Hedgehog signaling by direct binding of cyclopamine to Smoothened
The steroidal alkaloid cyclopamine has both teratogenic and antitumor activities arising from its ability to specifically block cellular responses to vertebrate Hedgehog signaling. We show here, using photoaffinity and fluorescent derivatives, that this inhibitory effect is mediated by direct bindin...
Gespeichert in:
| Veröffentlicht in: | Genes Dev |
|---|---|
| Hauptverfasser: | , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
Cold Spring Harbor Laboratory Press
2002
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| Schlagworte: | |
| Online-Zugang: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC187469/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12414725/ https://ncbi.nlm.nih.govhttps://doi.org/10.1101/gad.1025302 |
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