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Gli2 trafficking links Hedgehog-dependent activation of Smoothened in the primary cilium to transcriptional activation in the nucleus

Stimulation by the extracellular Hedgehog (Hh) protein signal has been shown to alter ciliary localization of the mammalian Hh receptor components Smoothened (Smo) and Patched (Ptc), and mutations that disrupt the structure and function of the cilium also disrupt Hh-induced changes in gene expressio...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Kim, Jynho, Kato, Masaki, Beachy, Philip A.
Format: Artigo
Sprache:Inglês
Veröffentlicht: National Academy of Sciences 2009
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2790365/
https://ncbi.nlm.nih.gov/pubmed/19996169
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0912180106
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