Smoothened Adopts Multiple Active and Inactive Conformations Capable of Trafficking to the Primary Cilium

Activation of Hedgehog (Hh) signaling requires the transmembrane protein Smoothened (Smo), a member of the G-protein coupled receptor superfamily. In mammals, Smo translocates to the primary cilium upon binding of Hh ligands to their receptor, Patched (Ptch1), but it is unclear if ciliary traffickin...

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Bibliografske podrobnosti
Main Authors: Wilson, Christopher W., Chen, Miao-Hsueh, Chuang, Pao-Tien
Format: Artigo
Jezik:Inglês
Izdano: Public Library of Science 2009
Teme:
Research Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2664476/
https://ncbi.nlm.nih.gov/pubmed/19365551
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0005182
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