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Smoothened Adopts Multiple Active and Inactive Conformations Capable of Trafficking to the Primary Cilium
Activation of Hedgehog (Hh) signaling requires the transmembrane protein Smoothened (Smo), a member of the G-protein coupled receptor superfamily. In mammals, Smo translocates to the primary cilium upon binding of Hh ligands to their receptor, Patched (Ptch1), but it is unclear if ciliary traffickin...
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| Hlavní autoři: | , , |
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| Médium: | Artigo |
| Jazyk: | Inglês |
| Vydáno: |
Public Library of Science
2009
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| Témata: | |
| On-line přístup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2664476/ https://ncbi.nlm.nih.gov/pubmed/19365551 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0005182 |
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